Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Supe...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ji, Daisy X, Witt, Kristen C, Kotov, Dmitri I, Margolis, Shally R, Louie, Alexander, Chevée, Victoria, Chen, Katherine J, Gaidt, Moritz M, Dhaliwal, Harmandeep S, Lee, Angus Y, Nishimura, Stephen L, Zamboni, Dario S, Kramnik, Igor, Portnoy, Daniel A, Darwin, K Heran, Vance, Russell E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248984/
https://ncbi.nlm.nih.gov/pubmed/34151776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67290
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