Synthesis and Cell Growth Inhibitory Activity of Six Non‐glycosaminoglycan‐Type Heparin‐Analogue Trisaccharides

The design and synthesis of heparin mimetics with high anticancer activity but no anticoagulant activity is an important task in medicinal chemistry. Herein, we present the efficient synthesis of five Glc‐GlcA‐Glc‐sequenced and one Glc‐IdoA‐Glc‐sequenced non‐glycosaminoglycan, heparin‐related trisac...

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Published in:ChemMedChem
Main Authors: Lisztes, Erika, Mező, Erika, Demeter, Fruzsina, Horváth, Lilla, Bősze, Szilvia, István Tóth, Balázs, Borbás, Anikó, Herczeg, Mihály
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247843/
https://ncbi.nlm.nih.gov/pubmed/33433040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000917
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