The nociceptin/orphanin FQ receptor system as a target to alleviate cancer‐induced bone pain in rats: Model validation and pharmacological evaluation

BACKGROUND AND PURPOSE: Cancer‐induced bone pain remains inadequately controlled, and current standard of care analgesics is accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic properties in rodent neuropathic and inflammatory...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Sliepen, Sonny H.J., Korioth, Johanna, Christoph, Thomas, Tzschentke, Thomas M., Diaz‐delCastillo, Marta, Heegaard, Anne‐Marie, Rutten, Kris
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
The Molecular Pharmacology of Bone and Cancer‐related Bone Diseases–Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246843/
https://ncbi.nlm.nih.gov/pubmed/31724155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14899
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