Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes

Human cytomegalovirus (HCMV) spreads and establishes a persistent infection within a host by stimulating the survival of carrier myeloid cells via the upregulation of Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins. However, the lack of potent Mcl-1-specific inhibitors and a targetabl...

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Pubblicato in:Antiviral Res
Autori principali: Burrer, Christine M., Auburn, Helen, Wang, Xu, Luo, Juntao, Abulwerdi, Fardokht A., Nikolovska-Coleska, Zaneta, Chan, Gary C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246402/
https://ncbi.nlm.nih.gov/pubmed/27914937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.11.027
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