A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury

Complement is known to play a role in ischemia and reperfusion injury (IRI). A general paradigm is that complement is activated by self-reactive natural IgM antibodies (nAbs), after they engage postischemic neoepitopes. However, a role for nAbs in lung transplantation (LTx) has not been explored. Us...

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Publicado no:Am J Transplant
Main Authors: Li, Changhai, Patel, Kunal, Tu, Zhenxiao, Yang, Xiaofeng, Kulik, Liudmila, Alawieh, Ali, Allen, Patterson, Cheng, Qi, Wallace, Caroline, Kilkenny, Jane, Kwon, Jennie, Gibney, Barry, Cantu, Edward, Sharma, Ashish, Pipkin, Mauricio, Machuca, Tiago, Emtiazjoo, Amir, Goddard, Martin, Holers, V. Michael, Nadig, Satish, Christie, Jason, Tomlinson, Stephen, Atkinson, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246004/
https://ncbi.nlm.nih.gov/pubmed/33210808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16404
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