Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation

The role of PI3K and Hippo signaling in chronic pancreatitis (CP) pathogenesis is unclear. Therefore, we assessed the involvement of these pathways in CP by examining the PI3K and Hippo signaling components PTEN and SAV1, respectively. We observed significant decreases in pancreatic PTEN and SAV1 le...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Tamura, Takeshi, Kodama, Takahiro, Sato, Katsuhiko, Murai, Kazuhiro, Yoshioka, Teppei, Shigekawa, Minoru, Yamada, Ryoko, Hikita, Hayato, Sakamori, Ryotaro, Akita, Hirofumi, Eguchi, Hidetoshi, Johnson, Randy L., Yokoi, Hideki, Mukoyama, Masashi, Tatsumi, Tomohide, Takehara, Tetsuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245178/
https://ncbi.nlm.nih.gov/pubmed/34032634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143414
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