Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation

The role of PI3K and Hippo signaling in chronic pancreatitis (CP) pathogenesis is unclear. Therefore, we assessed the involvement of these pathways in CP by examining the PI3K and Hippo signaling components PTEN and SAV1, respectively. We observed significant decreases in pancreatic PTEN and SAV1 le...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tamura, Takeshi, Kodama, Takahiro, Sato, Katsuhiko, Murai, Kazuhiro, Yoshioka, Teppei, Shigekawa, Minoru, Yamada, Ryoko, Hikita, Hayato, Sakamori, Ryotaro, Akita, Hirofumi, Eguchi, Hidetoshi, Johnson, Randy L., Yokoi, Hideki, Mukoyama, Masashi, Tatsumi, Tomohide, Takehara, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245178/
https://ncbi.nlm.nih.gov/pubmed/34032634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143414
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