Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8(+) T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence that islet epitope reactive T cells are pre...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rodriguez-Calvo, Teresa, Christoffersson, Gustaf, Bender, Christine, von Herrath, Matthias G., Mallone, Roberto, Kent, Sally C., James, Eddie A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8242234/
https://ncbi.nlm.nih.gov/pubmed/34220832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.683091
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