MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

Here we report that MYC rescues early human reprogramming cells from a proliferation pause induced by OCT3/4, SOX2 and KLF4 (OSK). We identified ESRG, as a marker of early reprogramming cells, which turned on as early as day 3 after OSK induction. On day 4, ESRG positive (+) cells converted to a TRA...

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Publicado en:Cell Rep
Autores principales: Rand, Tim, Sutou, Kenta, Tanabe, Koji, Jeong, Daeun, Nomura, Masaki, Kitaoka, Fumiyo, Tomoda, Emi, Narita, Megumi, Nakamura, Michiko, Nakamura, Masahiro, Watanabe, Akira, Rulifson, Eric, Yamanaka, Shinya, Takahashi, Kazutoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241223/
https://ncbi.nlm.nih.gov/pubmed/29641997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.057
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