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Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts
Pluripotency can be induced in somatic cells by forced expression of POU domain, class 5, transcription factor 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Kruppel-like factor 4 (KLF4), myelocytomatosis oncogene (c-MYC) (OSKM). However, factor-mediated direct reprogramming is generally regarde...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725041/ https://ncbi.nlm.nih.gov/pubmed/23812749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310291110 |
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