The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Pro-differentiation Genes

Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a broad array of cellular changes. Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving pro-differentiation factors,...

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Main Authors: Worringer, Kathleen A., Rand, Tim A., Hayashi, Yohei, Sami, Salma, Takahashi, Kazutoshi, Tanabe, Koji, Narita, Megumi, Srivastava, Deepak, Yamanaka, Shinya
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982312/
https://ncbi.nlm.nih.gov/pubmed/24239284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.11.001
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