Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy

Periplocymarin (PPM), a cardiac glycoside, has a narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity which hinder its wide clinical applications in cancer treatment. Herein, we report novel redox-responsive prodrug-nanoparticles (MPSSV-NPs) self-assembled by co-nanopr...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Deliv
Hauptverfasser: Zhang, Huiyun, Xu, Wenqian, Omari-Siaw, Emmanuel, Liu, Yingkun, Chen, Baoding, Chen, Deyu, Yu, Jiangnan, Xu, Ximing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241199/
https://ncbi.nlm.nih.gov/pubmed/28835137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1365393
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