Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation

Cardiac glycosides could increase intracellular Ca(2+) ion by inhibiting the Na(+)/K(+)ATPase to induce apoptosis in many tumor cells. However, narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity hinder their applications in cancer treatment. To improve the safety pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Hui-Yun, Xu, Wen-Qian, Zheng, Yuan-yuan, Omari-Siaw, Emmanuel, Zhu, Yuan, Cao, Xia, Tong, Shan-Shan, Yu, Jiang-nan, Xu, Xi-ming
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349917/
https://ncbi.nlm.nih.gov/pubmed/27861145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13389
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados