Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation

Cardiac glycosides could increase intracellular Ca(2+) ion by inhibiting the Na(+)/K(+)ATPase to induce apoptosis in many tumor cells. However, narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity hinder their applications in cancer treatment. To improve the safety pro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Zhang, Hui-Yun, Xu, Wen-Qian, Zheng, Yuan-yuan, Omari-Siaw, Emmanuel, Zhu, Yuan, Cao, Xia, Tong, Shan-Shan, Yu, Jiang-nan, Xu, Xi-ming
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349917/
https://ncbi.nlm.nih.gov/pubmed/27861145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13389
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