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Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice

Antisense oligonucleotide therapy for Duchenne muscular dystrophy has shown great potential in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few polyquaterniums (PQs) with different size and compositi...

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Dettagli Bibliografici
Pubblicato in:Drug Deliv
Autori principali: Wang, Mingxing, Wu, Bo, Shah, Sapana N, Lu, Peijuan, Lu, Qilong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241187/
https://ncbi.nlm.nih.gov/pubmed/28633548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1337827
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