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Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials. However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy. In...

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Foilsithe in:Mol Ther Nucleic Acids
Main Authors: Wang, Mingxing, Wu, Bo, Shah, Sapana N., Lu, Peijuan, Lu, Qilong
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Gene & Cell Therapy 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529765/
https://ncbi.nlm.nih.gov/pubmed/31121478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.04.023
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