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Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials. However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy. In...

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Bibliographic Details
Published in:Mol Ther Nucleic Acids
Main Authors: Wang, Mingxing, Wu, Bo, Shah, Sapana N., Lu, Peijuan, Lu, Qilong
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529765/
https://ncbi.nlm.nih.gov/pubmed/31121478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.04.023
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