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Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice

Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few saponins for their potential to improve delivery...

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Bibliografske podrobnosti
izdano v:Mol Ther Nucleic Acids
Main Authors: Wang, Mingxing, Wu, Bo, Shah, Sapana N., Lu, Peijuan, Lu, Qilong
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992344/
https://ncbi.nlm.nih.gov/pubmed/29858054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.02.004
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