The Mitochondrial Na(+)/Ca(2+) Exchanger Inhibitor CGP37157 Preserves Muscle Structure and Function to Increase Lifespan and Healthspan in Caenorhabditis elegans

We have reported recently that the mitochondrial Na(+)/Ca(2+) exchanger inhibitor CGP37157 extends lifespan in Caenorhabditis elegans by a mechanism involving mitochondria, the TOR pathway and the insulin/IGF1 pathway. Here we show that CGP37157 significantly improved the evolution with age of the s...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: García-Casas, Paloma, Alvarez-Illera, Pilar, Gómez-Orte, Eva, Cabello, Juan, Fonteriz, Rosalba I., Montero, Mayte, Alvarez, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241105/
https://ncbi.nlm.nih.gov/pubmed/34211399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.695687
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