Inhibition of Sarco-Endoplasmic Reticulum Ca(2+) ATPase Extends the Lifespan in C. elegans Worms

The sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) refills the endoplasmic reticulum (ER) with Ca(2+) up to the millimolar range and is therefore the main controller of the ER [Ca(2+)] level ([Ca(2+)](ER)), which has a key role in the modulation of cytosolic Ca(2+) signaling and ER-mitochondria C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: García-Casas, Paloma, Arias-del-Val, Jessica, Alvarez-Illera, Pilar, Fonteriz, Rosalba I., Montero, Mayte, Alvarez, Javier
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026643/
https://ncbi.nlm.nih.gov/pubmed/29988547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00669
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