mRNA Delivery of a Bispecific Single Domain Antibody to Polarize Tumor-associated Macrophages and Synergize Immunotherapy Against Liver Malignancies

Liver malignancies are among the tumor types that are resistant to immune checkpoint inhibition therapy. Tumor-associated macrophages (TAMs) are highly enriched and play a major role in inducing immunosuppression in liver malignancies. Herein, CCL2 and CCL5 are screened as two major chemokines respo...

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Bibliographische Detailangaben
Veröffentlicht in:Adv Mater
Hauptverfasser: Wang, Ying, Tiruthani, Karthik, Li, Sirui, Hu, Mengying, Zhong, Guojie, Tang, Yu, Roy, Sourav, Zhang, Lillian, Tan, Jun, Liao, Chengheng, Liu, Rihe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240965/
https://ncbi.nlm.nih.gov/pubmed/33945178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.202007603
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