Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

The ongoing COVID-19 pandemic has highlighted the dearth of approved drugs to treat viral infections, with only ∼90 FDA approved drugs against human viral pathogens. To identify drugs that can block SARS-CoV-2 replication, extensive drug screening to repurpose approved drugs is underway. Here, we sc...

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Bibliographic Details
Published in:bioRxiv
Main Authors: Schultz, David C., Johnson, Robert M., Ayyanathan, Kasirajan, Miller, Jesse, Whig, Kanupriya, Kamalia, Brinda, Dittmar, Mark, Weston, Stuart, Hammond, Holly L., Dillen, Carly, Castellana, Lauren, Lee, Jae Seung, Li, Minghua, Lee, Emily, Constant, Samuel, Ferrer, Marc, Thaiss, Christoph A., Frieman, Matthew B., Cherry, Sara
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240684/
https://ncbi.nlm.nih.gov/pubmed/34189531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.06.24.449811
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