Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening in human Huh7.5 cells validates 2...

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發表在:Cell Rep
Main Authors: Dittmar, Mark, Lee, Jae Seung, Whig, Kanupriya, Segrist, Elisha, Li, Minghua, Kamalia, Brinda, Castellana, Lauren, Ayyanathan, Kasirajan, Cardenas-Diaz, Fabian L., Morrisey, Edward E., Truitt, Rachel, Yang, Wenli, Jurado, Kellie, Samby, Kirandeep, Ramage, Holly, Schultz, David C., Cherry, Sara
格式: Artigo
語言:Inglês
出版: The Authors. 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985926/
https://ncbi.nlm.nih.gov/pubmed/33811811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108959
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