hPMSCs inhibit the expression of PD-1 in CD4(+)IL-10(+) T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway

BACKGROUND: The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regulating T cell responses. However, whether hPMSCs balance the redox metabolism of...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Zhang, Aiping, Zhang, Jiashen, Li, Xiaohua, Zhang, Hengchao, Xiong, Yanlian, Wang, Zhuoya, Zhao, Nannan, Wang, Feifei, Luan, Xiying
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240402/
https://ncbi.nlm.nih.gov/pubmed/34187557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02407-5
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