In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

IMPORTANCE: A publication reported that N-nitrosodimethylamine (NDMA), a probable human carcinogen, was formed when ranitidine and nitrite were added to simulated gastric fluid. However, the nitrite concentrations used were greater than the range detected in acidic gastric fluid in prior clinical st...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:JAMA Netw Open
Κύριοι συγγραφείς: Gao, Zongming, Karfunkle, Michael, Ye, Wei, Marzan, Tim Andres, Yang, Jingyue, Lex, Timothy, Sommers, Cynthia, Rodriguez, Jason D., Han, Xiaomei, Florian, Jeffry, Strauss, David G., Keire, David A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Medical Association 2021
Θέματα:
Original Investigation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://ncbi.nlm.nih.gov/pubmed/34181009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.18253
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