In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

IMPORTANCE: A publication reported that N-nitrosodimethylamine (NDMA), a probable human carcinogen, was formed when ranitidine and nitrite were added to simulated gastric fluid. However, the nitrite concentrations used were greater than the range detected in acidic gastric fluid in prior clinical st...

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書目詳細資料
發表在:JAMA Netw Open
Main Authors: Gao, Zongming, Karfunkle, Michael, Ye, Wei, Marzan, Tim Andres, Yang, Jingyue, Lex, Timothy, Sommers, Cynthia, Rodriguez, Jason D., Han, Xiaomei, Florian, Jeffry, Strauss, David G., Keire, David A.
格式: Artigo
語言:Inglês
出版: American Medical Association 2021
主題:
Original Investigation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://ncbi.nlm.nih.gov/pubmed/34181009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.18253
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