In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

IMPORTANCE: A publication reported that N-nitrosodimethylamine (NDMA), a probable human carcinogen, was formed when ranitidine and nitrite were added to simulated gastric fluid. However, the nitrite concentrations used were greater than the range detected in acidic gastric fluid in prior clinical st...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JAMA Netw Open
Prif Awduron: Gao, Zongming, Karfunkle, Michael, Ye, Wei, Marzan, Tim Andres, Yang, Jingyue, Lex, Timothy, Sommers, Cynthia, Rodriguez, Jason D., Han, Xiaomei, Florian, Jeffry, Strauss, David G., Keire, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Medical Association 2021
Pynciau:
Original Investigation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://ncbi.nlm.nih.gov/pubmed/34181009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.18253
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