In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

IMPORTANCE: A publication reported that N-nitrosodimethylamine (NDMA), a probable human carcinogen, was formed when ranitidine and nitrite were added to simulated gastric fluid. However, the nitrite concentrations used were greater than the range detected in acidic gastric fluid in prior clinical st...

詳細記述

保存先:
書誌詳細
出版年:JAMA Netw Open
主要な著者: Gao, Zongming, Karfunkle, Michael, Ye, Wei, Marzan, Tim Andres, Yang, Jingyue, Lex, Timothy, Sommers, Cynthia, Rodriguez, Jason D., Han, Xiaomei, Florian, Jeffry, Strauss, David G., Keire, David A.
フォーマット: Artigo
言語:Inglês
出版事項: American Medical Association 2021
主題:
Original Investigation
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239951/
https://ncbi.nlm.nih.gov/pubmed/34181009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.18253
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