A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome–associated kinase Dyrk1A overexpression

The highly conserved dual-specificity tyrosine phosphorylation–regulated kinase 1A (Dyrk1A) plays crucial roles during central nervous system development and homeostasis. Furthermore, its hyperactivity is considered responsible for some neurological defects in individuals with Down syndrome. We set...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Buchberger, Astrid, Schepergerdes, Lena, Flaßhoff, Maren, Kunick, Conrad, Köster, Reinhard W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239740/
https://ncbi.nlm.nih.gov/pubmed/34090874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100853
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