Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S

Glycoside hydrolases (GH) are a large family of hydrolytic enzymes found in all domains of life. As such, they control a plethora of normal and pathogenic biological functions. Thus, understanding selective inhibition of GH enzymes at the atomic level can lead to the identification of new classes of...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Si, Anshupriya, Jayasinghe, Thilina D., Thanvi, Radhika, Kapil, Sunayana, Ronning, Donald R., Sucheck, Steven J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238978/
https://ncbi.nlm.nih.gov/pubmed/34183716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92554-9
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