Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin–deficient neurons and fibroblasts

Defects or deficiencies in nuclear lamins cause pathology in many cell types, and recent studies have implicated nuclear membrane (NM) ruptures as a cause of cell toxicity. We previously observed NM ruptures and progressive cell death in the developing brain of lamin B1–deficient mouse embryos. We a...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chen, Natalie Y., Kim, Paul H., Tu, Yiping, Yang, Ye, Heizer, Patrick J., Young, Stephen G., Fong, Loren G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237679/
https://ncbi.nlm.nih.gov/pubmed/34161290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2107770118
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