Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3–amplified lung adenocarcinoma cells

A chromosome 1q21.3 region that is frequently amplified in diverse cancer types encodes phosphatidylinositol (PI)-4 kinase IIIβ (PI4KIIIβ), a key regulator of secretory vesicle biogenesis and trafficking. Chromosome 1q21.3–amplified lung adenocarcinoma (1q-LUAD) cells rely on PI4KIIIβ for Golgi-resi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Shi, Lei, Tan, Xiaochao, Liu, Xin, Yu, Jiang, Bota-Rabassedas, Neus, Niu, Yichi, Luo, Jiayi, Xi, Yuanxin, Zong, Chenghang, Creighton, Chad J., Glenn, Jeffrey S., Wang, Jing, Kurie, Jonathan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2021
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237628/
https://ncbi.nlm.nih.gov/pubmed/34155143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023537118
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