PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma

Heightened secretion of pro-tumorigenic effector proteins is a feature of malignant cells. Yet the molecular underpinnings and therapeutic implications of this feature remain unclear. Here we identify a chromosome 1q region that is frequently amplified in diverse cancer types and encodes multiple re...

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Pubblicato in:Sci Transl Med
Autori principali: Tan, Xiaochao, Banerjee, Priyam, Pham, Edward A., Rutaganira, Florentine U. N., Basu, Kaustabh, Bota-Rabassedas, Neus, Guo, Hou-Fu, Grzeskowiak, Caitlin L., Liu, Xin, Yu, Jiang, Shi, Lei, Peng, David H., Rodriguez, B. Leticia, Zhang, Jiaqi, Zheng, Veronica, Duose, Dzifa Y., Solis, Luisa M., Mino, Barbara, Raso, Maria Gabriela, Behrens, Carmen, Wistuba, Ignacio I., Scott, Kenneth L., Smith, Mark, Nguyen, Khanh, Lam, Grace, Choong, Ingrid, Mazumdar, Abhijit, Hill, Jamal L., Gibbons, Don L., Brown, Powel H., Russell, William K., Shokat, Kevan, Creighton, Chad J., Glenn, Jeffrey S., Kurie, Jonathan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702266/
https://ncbi.nlm.nih.gov/pubmed/31969487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax3772
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