PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma

Heightened secretion of pro-tumorigenic effector proteins is a feature of malignant cells. Yet the molecular underpinnings and therapeutic implications of this feature remain unclear. Here we identify a chromosome 1q region that is frequently amplified in diverse cancer types and encodes multiple re...

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發表在:Sci Transl Med
Main Authors: Tan, Xiaochao, Banerjee, Priyam, Pham, Edward A., Rutaganira, Florentine U. N., Basu, Kaustabh, Bota-Rabassedas, Neus, Guo, Hou-Fu, Grzeskowiak, Caitlin L., Liu, Xin, Yu, Jiang, Shi, Lei, Peng, David H., Rodriguez, B. Leticia, Zhang, Jiaqi, Zheng, Veronica, Duose, Dzifa Y., Solis, Luisa M., Mino, Barbara, Raso, Maria Gabriela, Behrens, Carmen, Wistuba, Ignacio I., Scott, Kenneth L., Smith, Mark, Nguyen, Khanh, Lam, Grace, Choong, Ingrid, Mazumdar, Abhijit, Hill, Jamal L., Gibbons, Don L., Brown, Powel H., Russell, William K., Shokat, Kevan, Creighton, Chad J., Glenn, Jeffrey S., Kurie, Jonathan M.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702266/
https://ncbi.nlm.nih.gov/pubmed/31969487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax3772
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