Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta

Osteogenesis imperfecta (OI) is a genetic disorder that features wide-ranging defects in both skeletal and nonskeletal tissues. Previously, we and others reported that loss-of-function mutations in FK506 Binding Protein 10 (FKBP10) lead to skeletal deformities in conjunction with joint contractures....

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lim, Joohyun, Lietman, Caressa, Grol, Matthew W., Castellon, Alexis, Dawson, Brian, Adeyeye, Mary, Rai, Jyoti, Weis, MaryAnn, Keene, Douglas R., Schweitzer, Ronen, Park, Dongsu, Eyre, David R., Krakow, Deborah, Lee, Brendan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237619/
https://ncbi.nlm.nih.gov/pubmed/34161280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100690118
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