Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

Alterations in the cGAS-STING DNA sensing pathway affect intestinal homeostasis. We sought to delineate the functional role of STING in intestinal inflammation. Increased STING expression was a feature of intestinal inflammation in mice with colitis and in humans afflicted with inflammatory bowel di...

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Veröffentlicht in:Immunity
Hauptverfasser: Shmuel-Galia, Liraz, Humphries, Fiachra, Lei, Xuqiu, Ceglia, Simona, Wilson, Ruth, Jiang, Zhaozhao, Ketelut-Carneiro, Natalia, Foley, Sage E., Pechhold, Susanne, Houghton, JeanMarie, Muneeruddin, Khaja, Shaffer, Scott A., McCormick, Beth A., Reboldi, Andrea, Ward, Doyle, Marshak-Rothstein, Ann, Fitzgerald, Katherine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237382/
https://ncbi.nlm.nih.gov/pubmed/34051146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.05.008
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