cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficiency of cGAS or STING in these models ameliorates dis...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Motwani, Mona, McGowan, Jason, Antonovitch, Jennifer, Gao, Kevin MingJie, Jiang, Zhaozhao, Sharma, Shruti, Baltus, Gretchen A., Nickerson, Kevin M., Marshak-Rothstein, Ann, Fitzgerald, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040952/
https://ncbi.nlm.nih.gov/pubmed/33854495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.605930
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