Improving the Gastrointestinal Stability of Linaclotide

[Image: see text] High susceptibility to proteolytic degradation in the gastrointestinal tract limits the therapeutic application of peptide drugs in gastrointestinal disorders. Linaclotide is an orally administered peptide drug for the treatment of irritable bowel syndrome with constipation (IBS-C)...

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Foilsithe in:J Med Chem
Main Authors: Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina, Muttenthaler, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2021
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237258/
https://ncbi.nlm.nih.gov/pubmed/33979161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00380
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