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Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency
[Image: see text] Voltage-gated sodium (Na(V)) channels are pore-forming transmembrane proteins that play essential roles in excitable cells, and they are key targets for antiepileptic, antiarrhythmic, and analgesic drugs. We implemented a heterobivalent design strategy to modulate the potency, sele...
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| Gepubliceerd in: | J Med Chem |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2020
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7667638/ https://ncbi.nlm.nih.gov/pubmed/33078946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01107 |
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