Heterobivalent ligands target cell-surface receptor combinations in vivo

A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as therapeutics themselves or as drug-antibody conjugates. However, antibodies suffer from their large size, which can lead to unfavorable pharm...

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Bibliographic Details
Main Authors: Xu, Liping, Josan, Jatinder S., Vagner, Josef, Caplan, Michael R., Hruby, Victor J., Mash, Eugene A., Lynch, Ronald M., Morse, David L., Gillies, Robert J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535626/
https://ncbi.nlm.nih.gov/pubmed/23236171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211762109
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