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Heterobivalent ligands target cell-surface receptor combinations in vivo
A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as therapeutics themselves or as drug-antibody conjugates. However, antibodies suffer from their large size, which can lead to unfavorable pharm...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535626/ https://ncbi.nlm.nih.gov/pubmed/23236171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211762109 |
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