Solid-Phase Synthetic Strategy & Bioevaluation of a Labeled δ-Opioid Receptor Ligand Dmt-Tic-Lys for In Vivo Imaging

[Image: see text] A general solid-phase synthetic strategy is developed to prepare fluorescent and/or lanthanide labeled derivatives of the δ-opioid receptor (δOR) ligand H-Dmt-Tic-Lys(R)-OH. The high δ-OR affinity (K(i) = 3 nM) and desirable in vivo characteristics of the Cy5 derivative 1 suggests...

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Detaylı Bibliyografya
Asıl Yazarlar: Josan, Jatinder S., Morse, David L., Xu, Liping, Trissal, Maria, Baggett, Brenda, Davis, Peg, Vagner, Josef, Gillies, Robert J., Hruby, Victor J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756606/
https://ncbi.nlm.nih.gov/pubmed/19445485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900200k
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