Comprehensive characterization of protein-protein interactions perturbed by disease mutations

Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein-protein interaction (PPI) networks within human cells. Here, we show that disease-associated germline variants are significantly enriched in sequences encodi...

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Publicat a:Nat Genet
Autors principals: Cheng, Feixiong, Zhao, Junfei, Wang, Yang, Lu, Weiqiang, Liu, Zehui, Zhou, Yadi, Martin, William R., Wang, Ruisheng, Huang, Jin, Hao, Tong, Yue, Hong, Ma, Jing, Hou, Yuan, Castrillon, Jessica A., Fang, Jiansong, Lathia, Justin D., Keri, Ruth A., Lightstone, Felice C., Antman, Elliott Marshall, Rabadan, Raul, Hill, David E., Eng, Charis, Vidal, Marc, Loscalzo, Joseph
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237108/
https://ncbi.nlm.nih.gov/pubmed/33558758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00774-y
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