Target identification among known drugs by deep learning from heterogeneous networks

Without foreknowledge of the complete drug target information, development of promising and affordable approaches for effective treatment of human diseases is challenging. Here, we develop deepDTnet, a deep learning methodology for new target identification and drug repurposing in a heterogeneous dr...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Zeng, Xiangxiang, Zhu, Siyi, Lu, Weiqiang, Liu, Zehui, Huang, Jin, Zhou, Yadi, Fang, Jiansong, Huang, Yin, Guo, Huimin, Li, Lang, Trapp, Bruce D., Nussinov, Ruth, Eng, Charis, Loscalzo, Joseph, Cheng, Feixiong
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150105/
https://ncbi.nlm.nih.gov/pubmed/34123272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04336e
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