Target identification among known drugs by deep learning from heterogeneous networks

Without foreknowledge of the complete drug target information, development of promising and affordable approaches for effective treatment of human diseases is challenging. Here, we develop deepDTnet, a deep learning methodology for new target identification and drug repurposing in a heterogeneous dr...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Zeng, Xiangxiang, Zhu, Siyi, Lu, Weiqiang, Liu, Zehui, Huang, Jin, Zhou, Yadi, Fang, Jiansong, Huang, Yin, Guo, Huimin, Li, Lang, Trapp, Bruce D., Nussinov, Ruth, Eng, Charis, Loscalzo, Joseph, Cheng, Feixiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150105/
https://ncbi.nlm.nih.gov/pubmed/34123272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04336e
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