NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer’s Disease–Related Proteins

Alzheimer’s disease (AD), the most prevalent form of dementia, affects globally more than 30 million people suffering from cognitive deficits and neuropsychiatric symptoms. Substantial evidence for the involvement of mitochondrial dysfunction in the development and/or progression of AD has been show...

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Udgivet i:Front Mol Biosci
Main Authors: Niederschweiberer, Moritz A., Schaefer, Patrick M., Singh, Larry N., Lausser, Ludwig, Bhosale, Devyani, Hesse, Raphael, Calzia, Enrico, Kestler, Hans A., Rueck, Angelika, Wallace, Douglas C., von Einem, Bjoern, von Arnim, Christine A. F.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Molecular Biosciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236706/
https://ncbi.nlm.nih.gov/pubmed/34195227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.671274
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