NEMO, a transcriptional target of estrogen and progesterone, is linked to tumor suppressor PML in breast cancer

The beneficial versus detrimental roles of estrogen plus progesterone (E+P) in breast cancer remains controversial. Here we report a beneficial mechanism of E+P treatment in breast cancer cells driven by transcriptional upregulation of the NFκB modulator NEMO, which in turn promotes expression of th...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Valdez, Kelli E., Elsarraj, Hanan S., Hong, Yan, Grimm, Sandra L., Ricci, Lawrence R., Fan, Fang, Tawfik, Ossama, May, Lisa, Cusick, Therese, Inciardi, Marc, Redick, Mark, Gatewood, Jason, Winblad, Onalisa, Hilsenbeck, Susan, Edwards, Dean P., Hagan, Christy, Godwin, Andrew K., Fabian, Carol, Behbod, Fariba
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236416/
https://ncbi.nlm.nih.gov/pubmed/28515148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2794
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