Extensive weight loss reduces glycan age by altering IgG N-glycosylation

BACKGROUND: Obesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation is a frequent posttranslational modification, highly responsive to inflammation and ageing. The prospect of biological age reduction, by changing glycosylat...

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Pubblicato in:Int J Obes (Lond)
Autori principali: Greto, Valentina L., Cvetko, Ana, Štambuk, Tamara, Dempster, Niall J., Kifer, Domagoj, Deriš, Helena, Cindrić, Ana, Vučković, Frano, Falchi, Mario, Gillies, Richard S., Tomlinson, Jeremy W., Gornik, Olga, Sgromo, Bruno, Spector, Tim D., Menni, Cristina, Geremia, Alessandra, Arancibia-Cárcamo, Carolina V., Lauc, Gordan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236401/
https://ncbi.nlm.nih.gov/pubmed/33941843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-021-00816-3
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