Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering

As genome engineering advances cell-based therapies, a versatile approach to introducing both CRISPR-Cas9 ribonucleoproteins (RNPs) and therapeutic transgenes into specific cells would be transformative. Autologous T cells expressing a chimeric antigen receptor (CAR) manufactured by viral transducti...

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Publicat a:Cell Rep
Autors principals: Hamilton, Jennifer R., Tsuchida, Connor A., Nguyen, David N., Shy, Brian R., McGarrigle, E. Riley, Sandoval Espinoza, Cindy R., Carr, Daniel, Blaeschke, Franziska, Marson, Alexander, Doudna, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236216/
https://ncbi.nlm.nih.gov/pubmed/34077734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109207
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