High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward their mass production. Perfused suspension culture (3D) of matri...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Manstein, Felix, Ullmann, Kevin, Kropp, Christina, Halloin, Caroline, Triebert, Wiebke, Franke, Annika, Farr, Clara‐Milena, Sahabian, Anais, Haase, Alexandra, Breitkreuz, Yannik, Peitz, Michael, Brüstle, Oliver, Kalies, Stefan, Martin, Ulrich, Olmer, Ruth, Zweigerdt, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2021
Assuntos:
Manufacturing for Regenerative Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235132/
https://ncbi.nlm.nih.gov/pubmed/33660952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0453
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