The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma

Pevonedistat is a neddylation inhibitor that blocks proteasomal degradation of cullin–RING ligase (CRL) proteins involved in the degradation of short-lived regulatory proteins, including those involved with cell-cycle regulation. We determined the sensitivity and mechanism of action of pevonedistat...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Foster, Jennifer H., Barbieri, Eveline, Zhang, Linna, Scorsone, Kathleen A., Moreno-Smith, Myrthala, Zage, Peter, Horton, Terzah M.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8234433/
https://ncbi.nlm.nih.gov/pubmed/34207315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126565
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