Synergistic anti-AML effects of the LSD1 inhibitor T-3775440 and the NEDD8-activating enzyme inhibitor pevonedistat via transdifferentiation and DNA rereplication

Lysine-specific demethylase 1A (LSD1, KDM1A) specifically demethylates di- and monomethylated histones H3K4 and K9, resulting in context-dependent transcriptional repression or activation. We previously identified an irreversible LSD1 inhibitor T-3775440, which exerts antileukemic activities in a su...

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Udgivet i:Oncogenesis
Main Authors: Ishikawa, Y, Nakayama, K, Morimoto, M, Mizutani, A, Nakayama, A, Toyoshima, K, Hayashi, A, Takagi, S, Dairiki, R, Miyashita, H, Matsumoto, S, Gamo, K, Nomura, T, Nakamura, K
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623902/
https://ncbi.nlm.nih.gov/pubmed/28892104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.76
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