Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage

Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppression, but also injures the various components of the...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Hu, Linping, Yin, Xiuxiu, Zhang, Yawen, Pang, Aiming, Xie, Xiaowei, Yang, Shangda, Zhu, Caiying, Li, Yapu, Zhang, Biao, Huang, Yaojin, Tian, Yunhong, Wang, Mei, Cao, Wenbin, Chen, Shulian, Zheng, Yawei, Ma, Shihui, Dong, Fang, Hao, Sha, Feng, Sizhou, Ru, Yongxin, Cheng, Hui, Jiang, Erlie, Cheng, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233686/
https://ncbi.nlm.nih.gov/pubmed/33881475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007362
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