Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells

Applying somatic cell reprogramming strategies in cancer cell biology is a powerful approach to analyze mechanisms of malignancy and develop new therapeutics. Here, we test whether leukemia cells can be reprogrammed in vivo using the canonical reprogramming transcription factors-Oct4, Sox2, Klf4, an...

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Опубликовано в: :Nat Commun
Главные авторы: Wang, Yajie, Lu, Ting, Sun, Guohuan, Zheng, Yawei, Yang, Shangda, Zhang, Hongyan, Hao, Sha, Liu, Yanfeng, Ma, Shihui, Zhang, Houyu, Ru, Yongxin, Gao, Shaorong, Yen, Kuangyu, Cheng, Hui, Cheng, Tao
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898631/
https://ncbi.nlm.nih.gov/pubmed/31811153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13411-y
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