Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

Mouse models of chronic myeloid malignancies suggest that targeting mature cells of the malignant clone disrupts feedback loops that promote disease expansion. Here, we show that in chronic myelomonocytic leukemia (CMML), monocytes that accumulate in the peripheral blood show a decreased propensity...

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Publicado en:Blood
Autores principales: Sevin, Margaux, Debeurme, Franck, Laplane, Lucie, Badel, Séverine, Morabito, Margot, Newman, Hanna L., Torres-Martin, Miguel, Yang, Qin, Badaoui, Bouchra, Wagner-Ballon, Orianne, Saada, Véronique, Sélimoglu-Buet, Dorothée, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fenaux, Pierre, Itzykson, Raphael, Braun, Thorsten, Etienne, Gabriel, Berthon, Celine, Thépot, Sylvain, Kepp, Oliver, Kroemer, Guido, Padron, Eric, Figueroa, Maria E., Droin, Nathalie, Solary, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2021
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233685/
https://ncbi.nlm.nih.gov/pubmed/33690800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008729
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