CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in neuroblastoma. Using RNA sequencing (RNA-seq) analysis, we sh...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Rep Med
Main Authors: Li, Nan, Torres, Madeline B., Spetz, Madeline R., Wang, Ruixue, Peng, Luyi, Tian, Meijie, Dower, Christopher M., Nguyen, Rosa, Sun, Ming, Tai, Chin-Hsien, de Val, Natalia, Cachau, Raul, Wu, Xiaolin, Hewitt, Stephen M., Kaplan, Rosandra N., Khan, Javed, St Croix, Brad, Thiele, Carol J., Ho, Mitchell
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233664/
https://ncbi.nlm.nih.gov/pubmed/34195677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100297
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki